Synergistic Combination of NAPROC-13 and NMR 13C DFT Calculations: A Powerful Approach for Revising the Structure of Natural Products Article uri icon

Abstracto

  • This article describes the structure revision of nine triterpenoids that have been reported corresponding to the same 13C NMR data set. In addition, 13C NMR calculation shows that some chemical shift assignments must be swapped. Our analysis improves the fit between the experimental and calculated data. Correcting misassigned structures and correctly assigning each signal is essential for elucidating new structurally related compounds. Furthermore, the ambiguity of several compounds, the structure of which differs in the literature and the Sci-Finder database, has been eliminated. Misassigned structures were found by chemical shift searches in NAPROC-13, and the results provide two or more different compounds with the same 13C NMR data. The process to determine the correct, most likely structural proposal in agreement with the experimental 13C NMR data was carried out by DFT calculations.

fecha de publicación

  • 2023

Palabras clave

  • Carbon,Chemical calculations,Chemical structure,Hydrocarbons,Nuclear magnetic resonance spectroscopyShow Less

PubMed Central ID

  • http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10616860/

Identificador único PubMed

  • 37675572